Search Results for: pedinno15

How can we make personalized therapy for childhood cancer a reality?

For some pediatric cancers, such as acute lymphoblastic leukemia, older forms of therapy — and older ways of defining who receives which therapy — have served well over the last few decades. But that approach is no longer sufficient. Revolutionary gains have been made in adult oncology using personalized genomic therapy — therapy based on matching…

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A filtration technology poised to cure sepsis

Sepsis is the most common cause of death in infants and children worldwide, and its incidence is increasing. Damage is caused not only by the bloodstream infection itself but by the systemic inflammatory cascade it triggers — which has been difficult to control without also causing long-lasting immune suppression. During a five-minute Ignite Talk at…

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A calmer rodent is a better rodent for pain medication research

The global market for pain medications is huge — some estimates predict it will hit $41.6 billion by 2017. However, the costs of pain medicine development are huge, too; it takes roughly $900 million to bring a new analgesic compound to market. In part, this is because some 80 percent of compounds that look promising…

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Accessible and affordable dialysis for children in developing countries

Children living outside industrialized nations have limited access to health care, and many children with severe kidney dysfunction do not have access to dialysis. Some developing countries have access to manual peritoneal dialysis, which requires the placement of a catheter into the abdominal cavity every one to two hours, 10 hours per day. But supplies…

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Mobile app lets doctors tell when a heart murmur is benign

More than half of all heart murmur referrals to pediatric cardiologists are for a Still’s murmur — a benign murmur that naturally occurs in 50 to 90 percent of children and goes away by adolescence. Every year, pediatric cardiologists in the United States see 1.3 million children with Still’s murmurs. That adds up to over…

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The power of the pulse: Ventriflo re-imagines cardiopulmonary support

Is there anything more fundamental to human life than the heartbeat? That thud, thud, thud — that reliable rhythm — is synonymous with being alive. When a person undergoes open-heart surgery, however, the heartbeat must be interrupted to give surgeons access to that essential organ. The organic pulse is temporarily replaced by a machine that…

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The future of pediatric precision medicine: opportunities, barriers

“Precision medicine” looks to be heading down the same path as “big data” and “innovation”: The term is becoming so widely used that it threatens to detract from the real impact it is already having in patients’ lives. But for children, who are still developing and have the most to gain, precision medicine is more…

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Storify: The Global Pediatric Innovation Summit in tweets

We’ve been covering the science and innovation news out of the Global Pediatric Innovation Summit + Awards all week. We close out with the event’s best one-liners and the attendees’ collective take on the talks, panels and announcements. Props go to @ldtimmerman and @cgcarlson for being the event’s top tweeters. Read on for Day 1…

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Two big wins for rare disease

Two new developments offer glimmers of hope to patients with rare, hard-to-diagnose conditions—validation of the power of crowd sourcing and the prospect of bringing cognitive computing to rare disease diagnosis. Both developments were announced at the Boston Children’s Hospital Global Pediatric Innovation Summit + Awards (#PedInno15). The crowd-sourcing challenge, CLARITY Undiagnosed, yesterday announced the findings of…

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From napkin sketch to new product: Rapid prototyping service speeds medical device development

Some people bring data and completed designs. Others just bring simple sketches. “We have this idea for this device,” they begin. “It may only help 15 kids a year, but it could really improve their quality of life.” Other people bring only a clinical need: “We need something to keep babies lying still after their…

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