Author: Jane Patrick

Blocking bad vessels: A new target for retinopathy, macular degeneration

blood vessels retinopathy

The development of blood vessels is a part of normal growth in almost all tissues. But it can also be pathological: Many eye conditions leading to blindness involve abnormal blood vessel formation, including retinopathy of prematurity in infants, diabetic retinopathy and wet, age-related macular degeneration (AMD).

Blood vessels produced under stress conditions such as inflammation or low oxygen, especially in the retina, are apt to be poorly constructed and leaky. Vascular endothelial growth factor, or VEGF, has been shown to contribute to pathologic vessel growth, and anti-VEGF treatments are now widely used to control the overproliferation of blood vessels, such as Lucentis for wet macular degeneration.

Unfortunately, VEGF-binding antibodies can block not just excess VEGF but the baseline normal amount needed for vessels and neighboring neurons to survive, with potentially serious side effects.

Read Full Story | Leave a Comment