Stories about: Information technology

Looking between seizures to map seizures’ origins

seizure mapping

When epilepsy can’t be controlled with drugs, neurosurgery is sometimes curative, if the seizures are coming from discrete brain tissue that can be safely removed.

Finding these diseased areas, however, can require invasive surgery to place grids of electrodes on the brain’s surface. That’s followed by long-term, 24-hour EEG monitoring — typically for a week — until a seizure happens. Neurosurgeons then use this data to map a surgical path. But to actually remove the diseased tissue, a second operation is needed.

That’s enough to deter many families from epilepsy surgery. But what if seizure origins could be mapped without having to actually observe a seizure?

Joseph Madsen, MD, director of Epilepsy Surgery at Boston Children’s Hospital, and Eun-Hyoung Park, PhD, a computational biophysicist in the Department of Neurosurgery, think they have a way to do that — with an algorithm originally used for economic forecasting. 

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Lessons from the data: Applying machine learning for clinical decision support

machine learning clinical decision support

Mauricio Santillana, PhD, faculty member in the Computational Health Informatics Program at Boston Children’s Hospital, had an idea as he witnessed the volume of continuous real-time data generated in the pediatric intensive care unit (PICU). He realized that tapping the data on patients’ ever-changing vital signs, with the help of machine-learning algorithms, could support clinical decision-making and predict (and help head off) up-coming health issues.

He started a dialogue with the hospital’s Innovation & Digital Health Accelerator, and now collaborates closely with clinicians in the PICU to create machine-learning algorithms that can help them provide the highest level of care.

“It’s fairly recent that clinicians realized people with backgrounds in math and statistics can be very helpful in a clinical context,” says Santillana

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2017 Innovators’ Showcase spotlights healthcare decision support

2017 Innovator's Showcase Boston Children's Hospital

Healthcare innovations will be on display next week — April 12 — at Boston Children’s Hospital’s Innovation & Digital Health Accelerator’s annual showcase. The event, from 3:30 to 5:30 p.m., will be kicked off by a discussion on clinical decision support with Doug Perrin, a bioengineer/computer scientist in Cardiac Surgery at Boston Children’s and Garry Steil, who is developing a glucose control technology for diabetes patients at the hospital.

Exhibits, demos and mingling will take place in the Patient Entertainment Center off the main hospital lobby (300 Longwood Avenue, Boston).

Among the roughly 20 apps, ventures and technologies on display:

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Developing a startup: bringing your healthcare innovation to market

a digital health startup

Sixth and last in an on-going series of Innovator’s Roadmap posts from Boston Children’s Hospital’s Innovation & Digital Health Accelerator (IDHA). Matt Murphy is Innovation Lead at IDHA.

We recently provided guidelines for selecting a platform and developing a Minimal Viable Product to take your digital health innovation beyond the prototype stage and create meaningful iterations. Once a Minimum Viable Product has been developed, numerous commercialization pathways are available, such as licensing an innovation to an existing company. But for many innovators, the best path may involve forming a startup company.

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7 digital health tips: Selecting a platform and developing a minimal viable product

digital health

Fifth in an ongoing series of Innovator’s Roadmap posts from Boston Children’s Hospital’s Innovation & Digital Health Accelerator (IDHA). Matt Murphy is Innovation Lead at IDHA.

We recently provided guidelines for developing prototypes of digital health products incorporating user-centered design and feedback from multiple sources. Let’s assume you’ve gone through multiple cycles of design updates, informed by your project goals and requirements, regulatory considerations and your long-term business or clinical strategy. Now, it’s time to select a technology platform and begin developing a fully functioning prototype of your innovation — your minimum viable product (MVP).

Below are some technical and tactical considerations to ensure your innovation’s long-term success and sustainability.

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4 tactical steps to designing for digital health

design digital health

Third in an ongoing series of Innovator’s Roadmap posts from Boston Children’s Hospital’s Innovation & Digital Health Accelerator (IDHA). Matt Murphy is Innovation Lead at IDHA.

We recently provided market sizing guidelines for healthcare innovators — strategies to help you determine your innovation’s total number of potential users and your sales opportunities. Next, we’ll take you through our approach to designing digital health products.

The research and design phase is a critical step in the development and commercialization of digital health innovations. This phase is often referred to as user-centered design or human factors design. It requires a significant investment in understanding your users (including clinicians, clinical teams, patients and/or caregivers) and their pain points (problems they repeatedly experience) before developing a technology-based solution.

In our initial consultations with innovators at Boston Children’s Hospital, we spend only a small amount of time discussing end technology solutions. Instead, we seek to understand the intended users, their pain points and how they will interact with the innovation, including clinical, workflow and business considerations.

It’s market research taken a step further. We recommend you follow a specific four-step procedure to optimize the research and design phase.

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7 digital health predictions for 2017

digital health predictions

What does 2017 have in store for digital healthcare innovations? Vector connected with clinical, digital health and business experts from the Innovation & Digital Health Accelerator (IDHA) at Boston Children’s Hospital and asked for their predictions.

Overall? “Expect to see a reshaping of the patient journey, more patient-centric care and more clinically impactful technology in 2017,” says John Brownstein, PhD, Chief Innovation Officer at the hospital. “We’re also looking forward to digital health offerings being met by industry-wide adoption as patient-centric care is provided and reimbursed.”

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Real-time contextual information could help doctors interpret children’s brain scans

Radiologists who can tune in to the nuances of brain scans in children are a pretty rarified group. Only about 3 percent of U.S. radiologists, some 800 to 900 physicians, practice in pediatrics. Those specifically trained in pediatric neuroradiology are even scarcer.

To a less trained eye, normal developmental changes in a child’s brain may be misinterpreted as abnormal on MRI. Conversely, a complex brain disorder can sometimes appear normal. That’s especially true when the abnormality affects both sides of the brain equally (see sidebar).

It can be hard to find the cause of a child’s developmental delay without a proper read. “Pediatric brain scans of children under age 4 can be particularly tricky to read because the brain is rapidly developing during this period,” says Sanjay Prabhu, MBBS, a pediatric neuroradiologist at Boston Children’s Hospital. “If you’re looking at adult scans all the time, it’s incredibly difficult to transition to pediatric scans and understand what is considered ‘normal’ and ‘abnormal.’ Clinicians often wonder, ‘Should I repeat the scan? Should I send the patient to a specialist?’”

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News Notes: Research and innovation news

A few things that caught Vector’s eye during the week:

FDA drug evaluation staff: An unmet need

overflowing inbox at FDA

New laws or initiatives to expedite drug approvals, especially for orphan drugs, have prompted the Food and Drug Administration to create new positions to review the applications. Unfortunately, these slots are proving hard to fill. Kaiser Health News reports that the FDA has more than 700 job vacancies in its Center for Drug Evaluation and Research (CDER), which approves new drugs. The problem? Pharma pays more — “roughly twice as much as we can,” said CDER director Janet Woodcock at a recent rare-disease summit. The 21st Century Cures Act, still awaiting Senate approval, could help by allowing the FDA to offer higher salaries and relaxing postgraduate degree requirements for some positions.

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Health care wants YOU: 9 opportunities, 4 pearls for digital health startups

digital health startups - reverse pitches
A visual summary of reverse digital health pitches (illustration: CollectiveNext).

Boston’s digital health world is humming with tech talent, idealistic health care professionals and business-savvy accelerator organizations. The passion was palpable last week as 300-plus people gathered at MassChallenge’s latest Pulse@Check digital health meetup, hoping to turn their health care ideas into reality.

The event, hosted by Boston Children’s Hospital’s Innovation and Digital Health Accelerator (IDHA) and Cerner, a lead developer of health care IT systems, presented numerous opportunities and tips for digital health startups.

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