Currently, there are five FDA-approved drugs for Alzheimer’s disease, but these only boost cognition temporarily and don’t address the root causes of Alzheimer’s dementia. Many newer drugs in the pipeline seek to eliminate amyloid plaque deposits or reduce inflammation in the brain, but by the time this pathology is detectable, it’s unlikely medications can do much to slow the disease.
A deep genetic analysis, involving nearly 65,000 people, finds a surprising risk factor for schizophrenia: variation in an immune molecule best known for its role in containing infection, known as complement component 4 or C4.
The findings, published this week in Nature, also support the emerging idea that schizophrenia is a disease of synaptic pruning, and could lead to much-needed new approaches to this elusive, devastating illness. …
As far back as she can remember, neuroscientist Beth Stevens, PhD, of the Boston Children’s Hospital Department of Neurology and the F.M. Kirby Neurobiology Center, has loved science. The concept of a career in the field began to take root in high school, nurtured in part by her biology teacher — a scientist on the side — who was both encouraging and inspiring.
Today, Stevens, winner of the 2015 MacArthur “genius” grant for her groundbreaking research on microglia cells, is doing her part to inspire a new generation of scientists and show them, as she says, “Scientists aren’t just nerdy guys in white coats.”
Hover over the objects in Stevens’s office to learn more about her work, life and innovations, and read more about her science.
When 2015 MacArthur “genius” grant winner Beth Stevens, PhD, began studying the role of glia in the brain in the 1990s, these cells—“glue” from the Greek—weren’t given much thought. Traditionally, glia were thought to merely protect and support neurons, the brain’s real players.
But Stevens, from the Department of Neurology and the F.M. Kirby Neurobiology Center at Boston Children’s Hospital, has made the case that glia are key actors in the brain, not just caretakers. Her work—at the interface between the nervous and immune systems—is helping transform how neurologic disorders like autism, amyotrophic lateral sclerosis (ALS), Alzheimer’s disease and schizophrenia are viewed. …