Stories about: Beth Stevens

Targeting synapse loss in Alzheimer’s to preserve cognition — before plaques appear

Alzheimer's microglia complement
Microglia (in red) consume synapses (in green) after mice are injected with the oligomeric form of beta-amyloid, before plaques appear in the brain. (Soyon Hong, Boston Children’s Hospital)

Currently, there are five FDA-approved drugs for Alzheimer’s disease, but these only boost cognition temporarily and don’t address the root causes of Alzheimer’s dementia. Many newer drugs in the pipeline seek to eliminate amyloid plaque deposits or reduce inflammation in the brain, but by the time this pathology is detectable, it’s unlikely medications can do much to slow the disease.

New research published in Science today suggests several ways that Alzheimer’s could be targeted much earlier to preserve cognitive function — before plaques or inflammation are evident.

Read Full Story | Leave a Comment

Genetic analysis backs a neuroimmune view of schizophrenia: Complement gone amok

schizophrenia C4
C4 (in green) located at the synapses of human neurons. (Courtesy Heather de Rivera, McCarroll lab)

A deep genetic analysis, involving nearly 65,000 people, finds a surprising risk factor for schizophrenia: variation in an immune molecule best known for its role in containing infection, known as complement component 4 or C4.

The findings, published this week in Nature, also support the emerging idea that schizophrenia is a disease of synaptic pruning, and could lead to much-needed new approaches to this elusive, devastating illness.

Read Full Story | 1 Comment | Leave a Comment

Behind the scenes in the brain: The work and life of Beth Stevens, PhD

As far back as she can remember, neuroscientist Beth Stevens, PhD, of the Boston Children’s Hospital Department of Neurology and the F.M. Kirby Neurobiology Center, has loved science. The concept of a career in the field began to take root in high school, nurtured in part by her biology teacher — a scientist on the side — who was both encouraging and inspiring.

Today, Stevens, winner of the 2015 MacArthur “genius” grant for her groundbreaking research on microglia cells, is doing her part to inspire a new generation of scientists and show them, as she says, “Scientists aren’t just nerdy guys in white coats.”

Hover over the objects in Stevens’s office to learn more about her work, life and innovations, and read more about her science.

Read Full Story | 1 Comment | Leave a Comment

Beth Stevens: A transformative thinker in neuroscience

When 2015 MacArthur “genius” grant winner Beth Stevens, PhD, began studying the role of glia in the brain in the 1990s, these cells—“glue” from the Greek—weren’t given much thought. Traditionally, glia were thought to merely protect and support neurons, the brain’s real players.

But Stevens, from the Department of Neurology and the F.M. Kirby Neurobiology Center at Boston Children’s Hospital, has made the case that glia are key actors in the brain, not just caretakers. Her work—at the interface between the nervous and immune systems—is helping transform how neurologic disorders like autism, amyotrophic lateral sclerosis (ALS), Alzheimer’s disease and schizophrenia are viewed.

Read Full Story | Leave a Comment