Stories about: Botulinum

Mutated botulinum neurotoxin B: A stronger player in the Botox world?

Clostridium botulinum

Famously associated with smoothing out wrinkles, botulinum toxin — better known as Botox — has been in use for 40 years now. Initially approved as a treatment for crossed eyes and then facial wrinkles, its on- and off-label uses today extend to urinary incontinence, migraines, perspiration, spasticity and even depression. But the diffusion of the toxin away from the injection site can also cause side effects like difficulty swallowing and drooping of the face.

Now, scientists have created an altered botulinum toxin, one that works much better than its natural version and with potentially fewer side effects. Their findings are written up in Nature Communications.

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