Stories about: cancer stem cells

Proposed cancer treatment may boost lung cancer stem cells, study warns

Epigenetic enzymes and lung cancer: Treating adenocarcinoma with G9a histone methyltransferase inhibitors leads to an increase in tumor cells with stem-like properties. In contrast, inhibiting histone demethylase prevents tumor growth. (SAMUEL ROWBOTHAM/BOSTON CHILDREN’S HOSPITAL)

Epigenetic therapies — targeting enzymes that alter what genes are turned on or off in a cell — are of growing interest in oncology as a way to make cancers less aggressive or less malignant. But now, at least one epigenetic therapy that had looked promising for lung cancer appears to boost the cancer stem cells that are believed to drive tumors. A study published today in Nature Communications also identifies a strategy that reduces these stem cells, curbing lung cancer in mice.

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The cell from hell: Can we outsmart cancer stem cells?

Cancer stem cells’ clever defenses may be the seeds of their undoing. (Image: leftover bacon/OpenClipArt)

Some scientists still debate the existence of cancer stem cells – rare cells that can singlehandedly perpetuate a tumor, and possibly make it more aggressive.  But others have moved on, isolating candidate cancer stem cells and documenting their distinctive characteristics and markers.

And some are starting to figure out how these cells operate and leverage that knowledge to come up with new approaches to cancer therapy.

Children’s scientist Markus Frank has been building quite a dossier on cancer stem cells, starting with melanoma stem cells. “Many of the features that make a cancer bad seem to be localized in this subpopulation of cells,” he says.

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