Stories about: cholera

Leveraging bacteria biofilms for vaccines

biofilm vaccine cholera
Through genetic engineering, this Vibrio cholerae biofilm can be loaded with extra antigens, creating a super-charged but inexpensive vaccine.

Malaria. Cholera. Now Ebola. Whatever the contagion, the need for new, or better, vaccines is a constant. For some of the most devastating public health epidemics, which often break out in resource-poor countries, vaccines have to be not only medically effective but also inexpensive. That means easy to produce, store and deliver.

Paula Watnick, MD, PhD, an infectious disease specialist at Boston Children’s Hospital, has a plan that stems from her work on cholera: using a substance produced by the bacteria themselves to make inexpensive and better vaccines against them.

Cells do all the work

Bacteria produce biofilms—a sticky, tough material composed of proteins, DNA and sugars—to help them attach to surfaces and survive.

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Tweeting in the time of cholera

Improving or maintaining access to clean drinking water is the best way to prevent a cholera epidemic. Twitter could prove an excellent way to help stop one. (Julien Harneis/Flickr)

It was after the devastating 2010 Haiti earthquake that mobile-friendly social media services like Twitter and Ushahidi came into their own as disaster management and relief tools. With the nation’s already unsteady infrastructure destroyed, these tools helped speed the deployment of people and supplies to where they were needed by giving relief workers on-the-ground intelligence about what was happening, what was needed and where in nearly real time.

With hindsight, Twitter and other informal data sources could also have sped up efforts to halt the spread of one of the disaster’s most feared aftermaths – cholera.

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