Stories about: cholesterol

Can breast cancer run on cholesterol?

Breast cancer cholesterol ezetimibe Zetia angiogenesisYou are what you eat, the saying goes. For some conditions (think cardiovascular disease or type 2 diabetes), there are clear connections between diet, health and illness.

For breast cancer, the picture is less clear. Many epidemiologic and laboratory studies have examined the Western diet (in particular, cholesterol) and its relation to breast cancer, with conflicting results.

“There’s been a raging debate in the field,” says Christine Coticchia, PhD, who works in the laboratory of Boston Children’s Hospital’s Vascular Biology Program director, Marsha Moses, PhD. “The biology of cancer and of cholesterol are so complex, and there are many subsets of breast cancer. In order to find any connections, you have to ask very specific questions.”

Banding together with Keith Solomon, PhD, in Boston Children’s Urology Department,  Coticchia and Moses asked whether dietary cholesterol might encourage progression of the most aggressive, so-called “triple-negative” breast tumors. As they report in the American Journal of Pathology, they found a big impact, at least in mice. But it’s too early to say just yet that cutting back on cholesterol will help women avoid breast cancer.

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Guidelines urging more cholesterol screening do not result in more kids on drugs

heart_screening cropped ShutterstockDespite recent national pediatric guidelines recommending identification and treatment of children with familial hypercholesterolemia, the use of lipid-lowering treatment has been flat over the past decade in real-world pediatric practice, finds a large multicenter study.

Justin Zachariah, MD, MPH, a pediatric cardiologist at Boston Children’s Hospital, presented the findings this week at the 2013 American Heart Association (AHA) Scientific Sessions. He believes they dispel some critiques of the recent guidelines, particularly concerns that more screening would result in overmedicating the pediatric population.

Extending beyond 2008 recommendations from the American Academy of Pediatrics, the 2011 National Heart, Lung and Blood Institute’s pediatric guidelines call for universal lipid screening and medical treatment for children at highest risk for early cardiovascular disease. One such high-risk condition is familial hypercholesterolemia, a genetic disorder characterized by high blood cholesterol levels, specifically very high levels of low-density lipoprotein (LDL, or “bad” cholesterol) and early coronary events.

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“Good” cholesterol could be even better for you than you thought

When you get on a long flight, there's always a risk of developing a deep vein thrombosis (DVT): a blood clot in your legs. But "good" cholesterol may be able to help stop DVTs from happening. (randomduck/Flickr)

Most of us are familiar with “good” and “bad” cholesterol. Low-density lipoprotein (LDL) is “bad” because it keeps cholesterol in the body, while the “goodness” of high-density lipoprotein (HDL) stems from its ability to scoop up old, used cholesterol and escort it to the liver for disposal. Because high levels of HDL in the blood are associated with lower risk of cardiovascular disease (a link that has recently come under question), it has received much attention from researchers.

And anyone who travels a great deal has probably heard about deep vein thrombosis or DVT, often cited as a good reason to get up and stretch your legs on a long flight. Restriction of normal blood flow—whether from being bedridden, paralyzed or sitting for hours on airplanes—is a major cause of blood clots in the legs. Though these clots can be painful in and of themselves, if they break free and travel to the lungs they can cause a potentially fatal pulmonary embolism. In fact, DVTs afflict nearly a million Americans each year and claim a quarter of a million lives.

Now a team from the lab of Denisa Wagner, PhD, of Boston Children’s Hospital’s Program in Cellular and Molecular Medicine and the Immune Disease Institute (PCMM/IDI), directed by Alexander Brill, MD, PhD, has found a connection between “good” cholesterol and DVT that may change the way these dangerous clots are treated—and perhaps prevented.

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The incredible shrinking hamster prostate

For most men, it’s just a matter of time until an enlarged prostate compels more frequent trips to the bathroom, day and night. A new study from Children’s researchers and colleagues implicates circulating cholesterol and suggests a potential new prevention and therapeutic strategy. The findings are reported in the October Journal of Urology.

The paper is an interesting culmination of a story that goes back nearly 40 years. And granted, it’s a hamster study, but if the research is able to go forward, it could mean a new use for an existing cholesterol-lowering drug.

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