Stories about: cognitive disorders

Dodging the long-term cognitive effects of early-life seizures

Seizures seem to strengthen and “lock in” synapses too soon, leaving no room for development. (Image: Ice synapses, Joe Flintham/Flickr)

It’s well known that babies who have seizures soon after birth have roughly a 50-50 chance of developing long-term intellectual and memory deficits and cognitive disorders like autism. But until now, it wasn’t understood why these deficits occur, much less how to prevent them from happening.

In the December 14 Journal of Neuroscience, researchers at Children’s Hospital Boston, led by neurologist-neuroscientist Frances Jensen, detail in a rat model how early-life seizures affect brain development at the cellular and molecular level. But more to the point, they show that it might be possible to ward off these effects with drug treatment soon after the seizure – using a drug called NBQX or similar drugs that are already approved by the FDA.

Jenson was particularly interested in what seizures do to synapses, the connections between neurons that are rapidly developing in the infant brain.

Read Full Story | 6 Comments | Leave a Comment

Science and innovation: top 10 for 2010

In my job as a science writer at Children’s, I comb the organization for interesting science and innovation stories that we can push out to various audiences. At the turn of the year, my colleagues ask me to recommend what I see as our top stories. We present this list to funders, industry and physicians who refer patients to us as a way to build our relationships. Today I’m sharing my 2010 list directly with you.

A couple of caveats:

Read Full Story | Leave a Comment