Stories about: David Briscoe

Can we tip the immune system toward transplant tolerance?

Shifting the balance of T cells toward Tregs might promote transplant tolerance
Turning on the DEPTOR gene shifts the immune system balance toward regulatory T cells (Tregs). This might promote transplant tolerance and perhaps curb autoimmune disorders. (Illustration: Fawn Gracey)

First in a two-part series on transplant tolerance. Read part two.

Although organ transplant recipients take drugs to suppress the inflammatory immune response, almost all eventually lose their transplant. A new approach, perhaps added to standard immunosuppressant treatment, could greatly enhance people’s long-term transplant tolerance, report researchers at Boston Children’s Hospital.

The approach, which has only been tested in mice as of yet, works by maintaining a population of T cells that naturally temper immune responses. It does so by turning on a gene called DEPTOR, which itself acts as a genetic regulator. In a study published July 3 in the American Journal of Transplantation, boosting DEPTOR in T cells enabled heart transplants to survive in mice much longer than usual.

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