Stories about: HIV prevention

Why evolution is the challenge — and the promise — in developing a vaccine against HIV

HIV surrounds and attacks a cell.
HIV surrounds and attacks a cell.

To fight HIV, the development of immunization strategies must keep up with how quickly the virus modifies itself. Now, Boston Children’s Hospital researchers are developing models to test HIV vaccines on a faster and broader scale than ever before with the support of the Bill & Melinda Gates Foundation.

“The field of HIV research has needed a better way to model the immune responses that happen in humans,” says Frederick Alt, PhD, director of the Boston Children’s Program in Cellular and Molecular Medicine, who is leading the HIV vaccine research supported by the Gates Foundation.

The researchers are racing against HIV’s sophisticated attack on the human immune system. HIV, the human immunodeficiency virus, mutates much faster than other pathogens. Within each infected patient, one virus can multiply by the billions.

Read Full Story | Leave a Comment

HIV prevention: Could fatty particles protect women worldwide from AIDS?

These hollow particles seemed to work with minimal tweaking.

HIV vaccines are in their infancy, and effective microbicides to prevent sexual transmission of HIV still don’t exist. Women, making up nearly half of the world’s 33 million HIV cases, are especially in need of protection. Here’s a new possible way for women to protect themselves before sex: an applicator filled with specially formulated fatty particles called liposomes.

The tiny spheres measure 4 microns in diameter, not visible without a microscope, and consist of a double outer layer of lipids (fats) and hollow centers. They’re relatively easy and cheap to engineer, and thus present a viable option for developing countries, where the cost of anti-HIV drugs, while falling, still bars access for most people.

In tests reported online this month in the journal Biomaterials, liposomes inhibited HIV infection in cell culture and appeared safe in female mice when given intravaginally.

Read Full Story | Leave a Comment