Stories about: magnets

Of magnets and bacteria: Filtering the blood of patients with sepsis

(Ryan Somma/Flickr)

There’s no other way to say it: sepsis is a horrible disease. It typically starts with a runaway bacterial infection in the blood, followed by a runaway immune response that severely damages the body it’s trying to save. The results: shock, multiple organ failure and—in between 210,000 and 375,000 people in the United States alone every year—death.

Part of the problem is that the methods available for treating sepsis aren’t particularly good. Antibiotics can kill the bacteria, but that still leaves bacterial debris floating in the bloodstream, fueling the already over-excited inflammatory response.

Removing the bacteria altogether—as fast as possible—would be the better solution. At least that’s what Daniel Kohane, MD, PhD, thinks. His lab at Boston Children’s Hospital’s Division of Critical Care Medicine has developed a new approach that combines magnetic nanoparticles, a synthetic molecule (called bis-Zn-DPA) that binds to the bacteria, and magnetized microfluidic devices to pull bacteria from the blood quickly and efficiently.

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