Stories about: PedInno15

Stuart Orkin honored for his lifetime research on blood development

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Presenter Bill Evans, IBM Watson Health and Stuart H. Orkin, MD

When colleagues describe Stuart H. Orkin, MD, associate chief of hematology/oncology at Boston Children’s Hospital and chair of pediatric oncology at Dana-Farber Cancer Institute, the words “immeasurable,” “vanguard” and “mentor” quickly roll off the tongue.

In honor of his 35-year career and commitment to blood cell research, Boston Children’s Hospital presented Orkin with the 2015 Lifetime Impact Award, during Boston Children’s Global Pediatric Innovation Summit held this week. The award recognizes a clinician and/or researcher who has significantly impacted pediatric care through practice-changing innovations or discoveries and made extraordinary and sustained leadership contributions in health care throughout his or her career.

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Leroy Hood and P4: How precision medicine will transform healthcare

Leroy Hood, MD, PhD, might not be a household name, but his impact on genetics and systems biology is hard to understate. Most notably, Hood invented the automated DNA sequencer that made the Human Genome Project possible.

In recent years, Hood has been working towards an even broader revolution in health care through an approach he calls P4 Medicine. The four Ps stand for predictive, preventative, personalized and participatory.

In his keynote presentation at the Boston Children’s Hospital Global Pediatric Innovation Summit + Awards, Hood laid out P4 Medicine’s radical vision for the future of health care. It’s a system that encompasses not just treating health problems, but enhancing wellness and preventing problems from occurring in the first place.

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Hematologist Vijay Sankaran receives Boston Children’s Hospital Rising Star Award

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Before an audience of several hundred luncheon attendees, physician-scientist Vijay G. Sankaran, MD, PhD, received Boston Children’s Hospital’s 2015 Rising Star Award — recognizing the outstanding achievements of an up-and-coming innovator under the age of 45 in pediatric health care.

Sankaran, a board-certified pediatric hematologist/oncologist with Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, conducts innovative research on red blood cell disorders such as Diamond-Blackfan anemia, sickle cell disease and thalassemia.

The Rising Star Award and companion Lifetime Impact Award ceremony were held at the hospital’s Global Pediatric Innovation Summit + Awards on November 10.

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Two big wins for rare disease

Two new developments offer glimmers of hope to patients with rare, hard-to-diagnose conditions—validation of the power of crowd sourcing and the prospect of bringing cognitive computing to rare disease diagnosis. Both developments were announced at the Boston Children’s Hospital Global Pediatric Innovation Summit + Awards (#PedInno15).

The crowd-sourcing challenge, CLARITY Undiagnosed, yesterday announced the findings of 21 teams that competed from seven countries. The winning team, Nationwide Children’s Hospital (Columbus, OH), was awarded $25,000. Invitae Corporation (San Francisco) and Wuxi NextCODE Genomics (Cambridge, MA) were named runners-up.

Each team received DNA sequences and clinical data from five families whose illnesses had eluded many prior diagnostic attempts—in some cases, even prior genomic sequencing.

“These were the toughest of the tough,” says Alan Beggs, PhD, co-organizer of CLARITY Undiagnosed and director of the Manton Center for Orphan Disease Research at Boston Children’s.

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IBM Watson Health and Medtronic: Where devices, data, and patient engagement meet

“When you’re dealing with a chronic disease like diabetes, 90 percent of medical care is done by the patients themselves,” says Jeff Ruiz, vice president of diabetes service and solutions at Medtronic. The time people with diabetes spend in the doctor’s office each year pales in comparison to the time they themselves spend managing their condition each and every day.

That’s why Medtronic, the world leader in diabetes management devices, is focused on patient engagement and turning real-time data into actionable insights. “You can provide all the best devices and medications, but it’s up to the patient at the end of the day,” said Ruiz, speaking on Monday during a panel discussion at the 2015 Boston Children’s Hospital Global Pediatric Innovation Summit + Awards.

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Aneesh Chopra: Five insights for innovators

In the mid-2000s, David Van Sickle, a researcher at the Centers for Disease Control and Prevention, had a hypothesis. He suspected asthma treatment might be overemphasizing direct patient intervention and underemphasizing broader environmental and health factors.

To test his hunch, Van Sickle enabled asthma inhalers with GPS technology and placed them in the hands of 1,000 people in Louisville, Kentucky. By tracking the time and location of asthma attacks and layering the results with open government data, Van Sickle discovered clusters of attacks in certain sections of the city — a finding that’s helping to clarify the link between asthma and environmental factors such as air quality.

According to Aneesh Chopra, cofounder of Hunch Analytics and the first-ever U.S. chief technology officer, Van Sickle — now the CEO of Propeller Health, a platform for respiratory health management — represents a new breed of health-care innovators who are using software and apps to draw insights from masses of data.

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Rock Health, Boston Children’s Hospital join to speed pediatric digital health startups

Bridget Duffy MDBoston Children’s Hospital and Rock Health, a venture fund dedicated to digital health, announced a strategic partnership aimed at accelerating pediatric health technologies during the hospital’s 2015 Global Pediatric Innovation Summit + Awards. Bridget Duffy, MD, is chair of Rock Health, chief Medical Officer of Vocera and co-founder of the Experience Innovation Network.

As a physician, entrepreneur, and especially as a parent, I am excited and inspired by a partnership between Rock Health and Boston Children’s Hospital to identify promising companies and cultivate emerging technologies focused on transforming pediatric care. Together, Rock Health and Boston Children’s Hospital will seed bigger ideas, accelerate adoption of new solutions, and massively change the way medicine is delivered to every child.

A global leader in pediatric clinical care, Boston Children’s Hospital will lend its expertise to support Rock Health’s portfolio and help shape the next generation of innovations. While Rock Health already has a proven track record with companies in this space, such as Kurbo Health, Cellscope and Kinsights, this close relationship with Boston Children’s will greatly accelerate the design and evaluation of new solutions, improving the health care experience for children and their caregivers.

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Questioning authority: A conversation with Martine Rothblatt

The more you listen to Martine Rothblatt, the more the fact that she’s transgendered becomes one of the less interesting things about her. Instead, you get caught up and inspired by her journey—from satellites to organ farms, from founding a pharmaceutical company to BINA 48, a “mindclone” robot that embodies her wife Bina’s beliefs, attitudes, memories and feelings.

Rothblatt, currently chief of United Therapeutics, is among the world’s highest paid female CEOs. Her motto is, “Do the right thing and the money will take care of itself.”

This is a lightly edited excerpt of her interview with Jane Clayson, guest host of NPR’s On Point.

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Innovation Tank: And the winner is … AIR

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Kevin Cedrone presents AIR to the judges at the Innovation Tank

“These start-ups are really looking to change the world. [They won’t be] the next Uber or Facebook. [Instead] they will really affect lives in the pediatric space,” said Troy Carter, founder and CEO of the entertainment company Atom Factory and newly named guest shark on ABC’s “Shark Tank,” as he introduced the Innovation Tank at the Boston Children’s Hospital Global Pediatric Innovation Summit + Awards.

Though each of the three participating innovations promised a tremendous impact on kids, the six judges agreed on the ultimate Innovation Tank winner and awarded a $30,000 investment to the Augmented Infant Resuscitator (AIR).

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Siddhartha Mukherjee: Have we lost the fire to tackle childhood cancers?

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Siddhartha Mukherjee, MD, PhD, takes his audience on a tour of 60 years’ worth of successes in cancer. What does the future hold?

We’ve all heard the George Santayana quote, “Those who cannot remember the past are condemned to repeat it.” But there’s another way of thinking about the lessons that the past holds for the future: Those who do remember the past can recapture and harness earlier feelings of energy, urgency and possibility to overcome new problems, now and in the future.

That line of thinking threaded its way throughout the keynote address oncologist Siddhartha Mukherjee, MD, PhD, author of The Emperor of All Maladies, delivered today at Boston Children’s Hospital’s Global Pediatric Innovation Summit + Awards 2015.

In taking the audience on a tour through the last 60 years of advances in cancer biology, genomics and treatment, Mukherjee highlighted the central role pediatrics played as the starting point for the cancer successes we see today. How, he asked, did children come to play such a central role? What can we learn from the successes in the 1950s and ’60s, when pediatric cancer started to evolve from a death sentence to a treatable, even curable disease?

And how, he asked, can we recapture and harness the energy and urgency of that time today?

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