Stories about: synapses

Targeting synapse loss in Alzheimer’s to preserve cognition — before plaques appear

Alzheimer's microglia complement
Microglia (in red) consume synapses (in green) after mice are injected with the oligomeric form of beta-amyloid, before plaques appear in the brain. (Soyon Hong, Boston Children’s Hospital)

Currently, there are five FDA-approved drugs for Alzheimer’s disease, but these only boost cognition temporarily and don’t address the root causes of Alzheimer’s dementia. Many newer drugs in the pipeline seek to eliminate amyloid plaque deposits or reduce inflammation in the brain, but by the time this pathology is detectable, it’s unlikely medications can do much to slow the disease.

New research published in Science today suggests several ways that Alzheimer’s could be targeted much earlier to preserve cognitive function — before plaques or inflammation are evident.

Read Full Story | Leave a Comment