Stories about: synthetic lethality

Probing the mystery of drug resistance: New hope for leukemia’s toughest cases

Alejandro Gutierrez, MD, was inspired by the deaths of three patients to figure out how leukemia cells become resistant to drugs.
Alejandro Gutierrez, MD
(PHOTO: MICHAEL GODERRE / BOSTON CHILDREN’S HOSPITAL)

Three children Alejandro Gutierrez, MD, treated for leukemia during his fellowship at Boston Children’s Hospital still haunt him more than a decade later. One 15-year-old boy died from the toxicity of the drugs he was given; the other two patients went through the whole treatment only to die when their leukemia came back. “That really prompted a deep frustration with the status quo,” Gutierrez recalls. “It’s motivated everything I’ve done in the lab since then.”

Gutierrez, now a researcher in the Division of Hematology/Oncology, has made it his mission to figure out why leukemia treatments cure some patients but not others. And in today’s issue of Cancer Cell, he and 15 colleagues report progress on two important fronts: They shed light on how leukemia cells become resistant to drugs, and they describe how two drugs used in combination may overcome that resistance, offering new hope to thousands of children and adults with leukemia.

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