Stories about: Viral infection

When asymptomatic viral infections turn deadly: Lessons from flies

Fruit flies

When Dr. Jonathan Kagan’s student came to him complaining of dying fruit flies, the two were unaware that their research was about to take an unexpected turn. Their goal in establishing Drosophila lines had been to study virus-host interactions. It was quickly subverted when the flies died on exposure to carbon dioxide, used when transferring flies between vials.

This was surprising on two fronts. First, carbon dioxide is routinely used to anesthetize the flies, with no ill effects. Second, the uninfected flies did not die. The virus used to infect the flies, called vesicular stomatitis virus (VSV), normally does not cause symptoms, even with the virus making several thousand copies of itself.

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