MIT’s implantable device could help docs determine best cancer medicine(Boston Business Journal)
Removing the trial and error associated with cancer drug treatments is high on oncologists’ wish lists. Heeding that call, MIT has developed an implantable device (about the size of a grain of rice) that can carry up to 30 different drug doses to a cancerous tumor, and then be removed to test responses.
In the U.S. alone, an estimated 30 million Americans suffer from a rare disorder. Many of them never receive a diagnosis, and often find themselves on a lonely journey, going from doctor to doctor and test to test, sometimes for many years, with no explanation for their symptoms.
How many people fall in the “undiagnosed” category is unclear, but in its first six years, the NIH’s Undiagnosed Diseases Program has received more than 10,000 inquiries. Without a diagnosis, it’s often difficult to qualify for insurance coverage, receive coordinated care or even connect with a support group.
What if the work of solving these medical mysteries could be crowd-sourced? That’s the goal of CLARITY Undiagnosed, an international challenge launching today in which scientific teams can compete to provide answers for five families with undiagnosed conditions. (Deadline for applications: June 11).
It may seem counterintuitive that your ability to tell different sounds apart would have anything to do with your ability to read or handle cognitive challenges. But that’s exactly what the lab of Nadine Gaab, PhD, has been showing.
Gaab discussed the research during a recent Longwood Seminar on Music as Medicine at Harvard Medical School:
The Gaab Lab has amassed an impressive body of work showing that auditory processing impairments correlate with developmental dyslexia, and that people who can detect tiny differences between sounds seem to do better both as musicians and as readers.
Your child’s forehead is warm, and you just took her temperature. The next question is, what to do about it? We all know that an average normal temp is 98.6°F, but is 100° a problem? Should 102° be a concern?
This is where Thermia comes in. It’s an online fever calculator developed by the HealthMap team at Boston Children’s Hospital. Essentially, it’s an educational tool aimed at helping concerned parents interpret a child’s temperature and understand which steps they should consider taking.
“I’m a father of two, and I still wonder sometimes what a temperature actually means,” says HealthMap co-founder John Brownstein, PhD. “We realized that there really aren’t any fever calculators out there to help parents answer that question.
“Our idea with Thermia,” he adds, “was to arm families with information so they don’t panic when their child has a temperature.”
[Update 5/18/15: According to a Wyss Institute press release, the Design Museum in London has selected the organs-on-chips as the winner of their 2015 Designs of the Year exhibition’s Product category.]
If you’re in New York City in the next few months, pop into the Museum of Modern Art (MoMA) and stop by the “This Is For Everyone: Design For The Common Good” exhibit. There—alongside displays dedicated to the “@” symbol, the pin icon from Google Maps and bricks made from living mushroom roots—you’ll find three small silicone blocks mounted on a wall panel.
Earlier this month, MoMA announced its plans to include the chips as part of their exploration of contemporary design in the digital age. In the museum’s eyes, organs-on-chips are more than a way to model disease in a complex, living system—they’re also art.
Seasonal Genes(The Scientist)
Our immune systems vary with the seasons, according to a study that could help explain why certain conditions such as heart disease and rheumatoid arthritis are aggravated in winter while people tend to be healthier in the summer.
Common vitamin reduces recurrence of some skin cancers(The Washington Post) Nicotinamide, a cheap over-the-counter vitamin, appears to reduce recurrence of some common skin cancers associated with sun exposure for people who have had them before, researchers at the University of Sydney report.
Protein production by the clock: mouse over to learn more. (Illustration: Yana Payusova, used with permission.)
Second in a two-part series on circadian biology and disease. Read part 1.
We are oscillating beings. Life itself arose among the oscillations of the waves and the oscillations between darkness and light. The oscillations are carried in our heartbeats and in our circadian sleep patterns.
A new study in Cell shows how these oscillations reach all the way down into our cells and help mastermind the timing of protein production.
Bruce Zetter, PhD, wears quite a few hats: Pioneer. Partner. Teacher. Mentor. Charles Nowiszewski Professor of Cancer Biology in Boston Children’s Hospital’s Department of Surgery.
Now, he’s adding crime fighter to the list. “The biggest crime in the health enterprise is when the next cure for Parkinson’s disease, cancer or multiple sclerosis is left on the bench because the researcher completed the discovery phase and decided that was enough,” he says. “So the breakthrough never becomes a drug or test.”
When you go into Netflix to choose a movie or Amazon to buy a book, they’re ready with proactive suggestions for your next purchase, based on your past history. Isaac Kohane, MD, PhD, would like to see something similar happening in medicine, where today, patients often find themselves repeating their medical history “again and again to every provider,” as Kohane recently told Harvard Medicine.
“Medicine as a whole is a knowledge-processing business that increasingly is taking large amounts of data and then, in theory, bringing that information to the point of care so that doctor and patient have a maximally informed visit,” says Kohane, chair of informatics at Boston Children’s Hospital and co-director of the Center for Biomedical Informatics at Harvard Medical School.